a tool for identifying drug-targetable redox-active disulphides

Metallothionein-2A

Intramolecular

Cysteine 45 and cysteine 51

A redox-regulated disulphide may form within Metallothionein-2A between cysteines 45 and 51 (44 and 50 respectively in this structure).

Details

Redox score ?

99

PDB code

Structure name

three-dimensional structure of rabbit liver cd7 metallothionein-2a in aqueous solution determined by nuclear magnetic resonance

Structure deposition date

1990-05-14

Thiol separation (Å)

3

Half-sphere exposure sum ?

51

Minimum pK_a ?

3

% buried

0

Peptide accession

Residue number A

45

Residue number B

51

Peptide name

Metallothionein-2A

Ligandability

Cysteine 45 of Metallothionein-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Metallothionein-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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